Synthesis of nodulisporic acid 2 ''-oxazoles and 2 ''-thiazoles

Authors
Berger, R Shoop, WL Pivnichny, JV Warmke, LM Zakson-Aiken, M Owens, KA deMontigny, P Schmatz, DM Wyvratt, MJ Fisher, MH Meinke, PT Colletti, SL
Citation
R. Berger et al., Synthesis of nodulisporic acid 2 ''-oxazoles and 2 ''-thiazoles, ORG LETT, 3(23), 2001, pp. 3715-3718
Citations number
21
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
3
Issue
23
Year of publication
2001
Pages
3715 - 3718
Database
ISI
SICI code
1523-7060(20011115)3:23<3715:SONA2'>2.0.ZU;2-8
Abstract
[GRAPHICS] The semisynthetic conversion of nodulisporic acid A(1) into a set of three heterocyclic side chain derivatives provided compounds, highlighted by 6, w ith an improved spectrum of ectoparasiticidal activity and pharmacokinetic profile relative to the natural product.