An efficient combination of microwave dielectric heating and the use of solid-supported triphenylphosphine for Wittig reactions

[GRAPHICS] Olefins could be formed in an efficient way by the use of stable ylides in just a few minutes using microwave dielectric heating. The drawback with th e Wittig reaction in solution phase is the formation of I equiv of tripheny lphosphine oxide. To avoid this, the corresponding protocol using the effic ient combination of solid-supported triphenylphosphine and microwave dielec tric heating was developed. An even more efficient one-pot three-step Witti g reaction was also developed.