Intracerebroventricular injection of fusaric acid attenuates the anorexia by glucagon-like, peptide-1 in the neonatal chick

It is known that central injection of glucagon-like peptide-1 (GLP-1) suppr esses feeding in rats and chicks, but the systems for GLP-1 are still open with special reference to the chick. The present study was done to determin e whether a noradrenergic mechanism contributes to the anorexigenic effect of GLP-1 on the neonatal chick. Central administration of norepinephrine (N E) suppressed food intake with narcolepsy as GLP-1 in chicks. However, in s pite of that dopamine (DA) did not affect food intake, coadministration of inhibitor of dopamine-beta -hydroxylase (DBH), fusaric acid (FA), attenuate d the suppressive effect of GLP-1 on feeding behavior. It is suggested that there may be the interactive relationships between GLP-1 and noradrenergic system in the neonatal chick. (C) 2001 Elsevier Science Inc. All rights re served.