Retrometabolic drug design - novel aspects, future directions

A brief overview of the general, retrometabolic drug design principles, inc luding soft drug and chemical delivery system design, is presented. Selecte d recent developments within these fields are also summarized, including re sults related to the design of soft bufuralol and amiodarone analogues, to the airway activity of loteprednol etabonate, a soft corticosteroid, and to the brain targeted delivery of some neuropeptides.