Non-solvent shock agglomerated ibuprofen: production and evaluation of retarded formulations

Conventional and prepared racemic and optically pure substances were assess ed with regard to their suitability to be processed into retarded formulati ons by direct tabletting. In this respect conventional ibuprofen and specia lly granulated substances usually show only insufficient properties. Fluid bed granulated S(+)ibuprofen, however, can be suitably transformed into slo w release forms by using traditional agents (above all cellulose ether); th e low bulk and tapped volume of these granulates, however, is a limiting fa ctor. Shock agglomerated ibuprofen (in particular racemic substance) offers all preconditions of dissolution in acid environment correspondingly prepa red substances can cause significant release retardation in artificial inte stinal juice. Moreover acceptable tablet qualities (e.g. hardness) can be g uaranteed.