KINETIC-BEHAVIOR OF SOME ACETYLENIC INDOLALKYLAMINE DERIVATIVES AND THEIR CORRESPONDING PARENT AMINES

Different methoxy indolalkylamines based on a common structure, and di ffering in the side chain attached at the 2 position of the indole rin g were studied as MAO A inhibitors. Some are acetylenic derivatives an d consequently might behave as ''suicide'' MAO inhibitors (FA 42, FA 4 3, FA 45). The rest of compounds are the corresponding parent amines a nd they might behave as MAO substrates (FA 51, FA 52, FA 53, FA 54). T he kinetic behaviour of the parent amines as MAO A and MAO B inhibitor s and substrates was determined. In case of acetylenic derivatives, ki netic constants defining the non-covalent adduct formation and the cov alent adduct formation were also calculated for the mechanism-based in hibition. These parameters will allow us to establish the correlation with structural features that predetermine one compound to be a good M AO substrate or a good MAO A and MAO B inhibitor.