Phenolic compounds with anti-inflammatory activity from Eupatorium buniifolium

Authors
Muschietti, L Gorzalczany, S Ferraro, G Acevedo, C Martino, V
Citation
L. Muschietti et al., Phenolic compounds with anti-inflammatory activity from Eupatorium buniifolium, PLANTA MED, 67(8), 2001, pp. 743-744
Citations number
14
Categorie Soggetti
Pharmacology & Toxicology
Journal title
PLANTA MEDICA
ISSN journal
00320943 → ACNP
Volume
67
Issue
8
Year of publication
2001
Pages
743 - 744
Database
ISI
SICI code
0032-0943(200111)67:8<743:PCWAAF>2.0.ZU;2-C
Abstract
Anti-inflammatory activity was detected in the CH2Cl2 extract of the aerial parts of Eupatorium buniifolium using the TPA-mouse ear model. Three compo unds isolated from this extract, by bioassay-guided fractionation, signific antly inhibited the inflammatory response. The compounds were identified as 5,7,5'-trihydroxy-3,6,2',4'-tetramethoxyflavone (1), scopoletin (2) and ce ntaureidin (3) which inhibited the edema by 67.3 %, 59.8 % and 49.7 %, resp ectively, at a dose of 1 mg/ear.