Bakuchiol: A hepatoprotective compound of Psoralea corylifolia on tacrine-induced cytotoxicity in Hep G2 cells

Authors
Cho, H Jun, JY Song, EK Kang, KH Baek, HY Ko, YS Kim, YC
Citation
H. Cho et al., Bakuchiol: A hepatoprotective compound of Psoralea corylifolia on tacrine-induced cytotoxicity in Hep G2 cells, PLANTA MED, 67(8), 2001, pp. 750-751
Citations number
8
Categorie Soggetti
Pharmacology & Toxicology
Journal title
PLANTA MEDICA
ISSN journal
00320943 → ACNP
Volume
67
Issue
8
Year of publication
2001
Pages
750 - 751
Database
ISI
SICI code
0032-0943(200111)67:8<750:BAHCOP>2.0.ZU;2-Y
Abstract
Bioassay-guided fractionation of the H2O extract of the seeds of Psoralea c orylifolia furnished one hepatoprotective compound, bakuchiol (1), together with two moderately active compounds, bakuchicin (2) and psoralen (3), on tacrine-induced cytotoxicity in human liver-derived Hep G2 cells. The EC50 values of compounds 1 - 3 are 1.0, 47.0, 50.0 mug/ml, respectively. Silymar in as a positive control showed the EC50 value with 5.0 mug/ml.