Hypotensive effect of chemical constituents from Aloe barbadensis

Authors
Saleem, R Faizi, S Siddiqui, BS Ahmed, M Hussain, SA Qazi, A Dar, A Ahmad, SI Qazi, MH Akhtar, S Hasnain, SN
Citation
R. Saleem et al., Hypotensive effect of chemical constituents from Aloe barbadensis, PLANTA MED, 67(8), 2001, pp. 757-760
Citations number
20
Categorie Soggetti
Pharmacology & Toxicology
Journal title
PLANTA MEDICA
ISSN journal
00320943 → ACNP
Volume
67
Issue
8
Year of publication
2001
Pages
757 - 760
Database
ISI
SICI code
0032-0943(200111)67:8<757:HEOCCF>2.0.ZU;2-7
Abstract
Hypotensive effects of aloeemodin, aloin A, elgonica dimer A and bisbenzopy ran from Aloe barbodensis have been studied. Aloeemodin has emerged as a po tent hypotensive agent in current pharmacological investigations and caused 26%, 52%, and 79% falls in mean arterial blood pressure at the correspondi ng doses of 0.5, 1, and 3 mg/kg in rats. The paper also describes the absol ute configuration of elgonica dimer A (1).