Effect of trans-dehydrocrotonin, a 19-nor-clerodane diterpene from Croton cajucara on experimental hypertriglyceridaemia and hypercholesterolaemia induced by Triton WR 1339 (tyloxapol) in mice
Rm. Silva et al., Effect of trans-dehydrocrotonin, a 19-nor-clerodane diterpene from Croton cajucara on experimental hypertriglyceridaemia and hypercholesterolaemia induced by Triton WR 1339 (tyloxapol) in mice, PLANTA MED, 67(8), 2001, pp. 763-765
The effect of trans-dehydrocrotonin (t-DCTN) from Croton cajucara Benth. wa
s investigated in mice on Triton WR 1339 (tyloxapol)-induced hypercholester
olaemia and hypertriglyceridaemia. Mice treated with single application of
tyloxapol (400 mg/kg, i.p.) demonstrated significantly increased blood leve
ls of total cholesterol and triglycerides at 24 h and 48 h after its inject
ion, compared to normal controls. These increases were found to be markedly
suppressed in animals treated orally with 25 and 50 mg/kg t-DCTN or 100 mg
/kg gemfibrozil, an established antihypercholesterolaemic drug. These resul
ts suggest that t-DCTN may be a suitable candidate for combating pathologie
s associated with hyperlipaemia.