O. Curet et al., EFFECTS OF BEFLOXATONE, A NEW POTENT REVERSIBLE MAO-A INHIBITOR, ON CORTEX AND STRIATUM MONOAMINES IN FREELY MOVING RATS, Journal of neural transmission. Supplementum, (41), 1994, pp. 349-355
Single administration of befloxatone (0.75 mg/kg, i.p.) in the rat inc
reased extracellular levels of DA (+300%) in striatum. In frontal cort
ex, befloxatone (0.75 mg/kg, i.p.) and nialamide (100 mg/kg, i.p.) inc
reased NA by +100% but did not modify 5HT, whereas pargyline (100 mg/k
g i.p.) increased extracellular NA and 5HT by 400 and 600%, respective
ly. At these doses, befloxatone inhibited totally and selectively MAO-
A, pargyline inhibited totally MAO-A and MAO-B. Increases of tissue an
d extracellular concentrations of NA and 5HT were highest after Pargyl
ine suggesting that both monoamines may be metabolized by MAO-A and MA
O-B. Befloxatone and nialamide potentiated the effects of idazoxan (20
mg/kg, i.p.) on extracellular NA in frontal cortex, which increased f
rom 350% to 2,000 and 1,500% respectively. These results suggest that
alpha(2)-adrenoceptors play a major role in the regulation of extracel
lular NA in frontal cortex.