Occupational lung disease comprises a wide variety of disorders caused by t
he inhalation or ingestion of dust particles or noxious chemicals. These di
sorders include pneumoconiosis, asbestos-related pleural and parenchymal di
sease, chemical pneumonitis, occupational infection, hypersensitivity pneum
onitis, and organic dust toxic syndrome. Most of these disorders produce di
ffuse lung disease. Although many of the disorders can be detected at chest
radiography, high-resolution computed tomography (CT) has been shown to be
superior to chest radiography in depicting parenchymal, airway, and pleura
l abnormalities. Some occupational lung diseases have characteristic radiol
ogic features suggesting the correct diagnosis, whereas in others, a combin
ation of clinical features, related occupational history, radiologic findin
gs, and literature supporting an association between the exposure and the d
isease process is required for diagnosis. With advances in chest radiology
including high-resolution CT, radiologists play a key role in the clinical
evaluation of occupational lung diseases and should continue their involvem
ent in the diagnosis and treatment of these diseases.