Effect of hydroxycitric acid on serotonin release from isolated rat brain cortex

There is evidence that hydroxycitric acid (HCA), an extract of dried fruit rind of South Asian trees of the genus Garcinia cambogia, can reduce food i ntake in experimental animals. In the present study, we investigated the ef fect of HCA on basal and potassium-depolarization evoked increase in radiol abeled serotonin ([H-3]-5-HT) release from rat brain cortex slices in vitro . HCA (10 muM-1 mM) altered the baseline of spontaneous tritium efflux but had no significant effect on potassium-evoked release of [H-3]-5-HT. When a pplied on its own, HCA (10 muM-1 mM) elicited a concentration-dependent inc rease in efflux of [H-3]-5-HT reaching a maximum at 300 muM. We conclude th at HCA can increase the release of radiolabeled 5-HT from the isolated rat brain cortex.