Production of recombinant endostatin in milk of transgenic mice

Authors
Zavadskaya, ES Zacharova, ES Kadulin, SG Kibardin, AV Kiselev, SL Gnuchev, NV
Citation
Es. Zavadskaya et al., Production of recombinant endostatin in milk of transgenic mice, RUSS J GEN, 37(9), 2001, pp. 1009-1013
Citations number
17
Categorie Soggetti
Molecular Biology & Genetics
Journal title
RUSSIAN JOURNAL OF GENETICS
ISSN journal
10227954 → ACNP
Volume
37
Issue
9
Year of publication
2001
Pages
1009 - 1013
Database
ISI
SICI code
1022-7954(200109)37:9<1009:POREIM>2.0.ZU;2-5
Abstract
Using the bovine alpha S1-casein gene, a genetic construct with an endostat in-coding fragment of the mouse collagen XVIII cDNA was designed to express endostatin in milk of transgenic animals. Several transgenic mice were obt ained. The mice secreted endostatin in milk at 70-300 ng/mul and transmitte d this character to their progeny.