Mi. Shadrina et al., Polymorphism of the angiotensin-converting enzyme gene in patients with coronary heart disease from the Moscow population, RUSS J GEN, 37(4), 2001, pp. 432-435
The insertion/deletion (I/D) polymorphism, of the angiotensin-converting en
zyme (ACE) gene was studied in patients with coronary heart disease (CHD) a
nd healthy individuals randomly sampled from the Moscow population. The ACE
gene proved to be associated with the plasma apolipoprotein B (ApoB) conte
nt in CHD patients, but not associated with HCD development in individuals
with elevated serum cholesterol and triglycerides. An association was not r
evealed between the alleles of the ACE gene and hypertension in CHD patient
s.