Polymorphism of the angiotensin-converting enzyme gene in patients with coronary heart disease from the Moscow population

Authors
Shadrina, MI Slominskii, PA Miloserdova, OV Perova, NV Limborskaya, SA
Citation
Mi. Shadrina et al., Polymorphism of the angiotensin-converting enzyme gene in patients with coronary heart disease from the Moscow population, RUSS J GEN, 37(4), 2001, pp. 432-435
Citations number
16
Categorie Soggetti
Molecular Biology & Genetics
Journal title
RUSSIAN JOURNAL OF GENETICS
ISSN journal
10227954 → ACNP
Volume
37
Issue
4
Year of publication
2001
Pages
432 - 435
Database
ISI
SICI code
1022-7954(200104)37:4<432:POTAEG>2.0.ZU;2-X
Abstract
The insertion/deletion (I/D) polymorphism, of the angiotensin-converting en zyme (ACE) gene was studied in patients with coronary heart disease (CHD) a nd healthy individuals randomly sampled from the Moscow population. The ACE gene proved to be associated with the plasma apolipoprotein B (ApoB) conte nt in CHD patients, but not associated with HCD development in individuals with elevated serum cholesterol and triglycerides. An association was not r evealed between the alleles of the ACE gene and hypertension in CHD patient s.