Association between the insertion/deletion polymorphism of the angiotensin-converting enzyme gene and angiopathy in patients with non-insulin dependent diabetes mellitus in Chuvash Republic
Ov. Miloserdova et al., Association between the insertion/deletion polymorphism of the angiotensin-converting enzyme gene and angiopathy in patients with non-insulin dependent diabetes mellitus in Chuvash Republic, RUSS J GEN, 37(1), 2001, pp. 98-101
Insertion/deletion polymorphism of the angiotensin-converting enzyme (ACE)
gene was analyzed in patients with non-insulin-dependent diabetes mellitus
(NIDDM) and in the control group consisting of healthy subjects. The insert
ion allele (I) and genotype II were found to be associated with NIDDM. The
frequencies of diabetic retinopathy and nephropathy in NIDDM patients were
not associated with this polymorphism. However, an association was found be
tween the DD genotype of the ACE gene and diabetic angiopathy in lower extr
emities.