Association between the insertion/deletion polymorphism of the angiotensin-converting enzyme gene and angiopathy in patients with non-insulin dependent diabetes mellitus in Chuvash Republic

Authors
Miloserdova, OV Slominsky, PA Mauyanov, IV Markov, DS Balabolkin, MI Limborska, SA
Citation
Ov. Miloserdova et al., Association between the insertion/deletion polymorphism of the angiotensin-converting enzyme gene and angiopathy in patients with non-insulin dependent diabetes mellitus in Chuvash Republic, RUSS J GEN, 37(1), 2001, pp. 98-101
Citations number
22
Categorie Soggetti
Molecular Biology & Genetics
Journal title
RUSSIAN JOURNAL OF GENETICS
ISSN journal
10227954 → ACNP
Volume
37
Issue
1
Year of publication
2001
Pages
98 - 101
Database
ISI
SICI code
1022-7954(200101)37:1<98:ABTIPO>2.0.ZU;2-4
Abstract
Insertion/deletion polymorphism of the angiotensin-converting enzyme (ACE) gene was analyzed in patients with non-insulin-dependent diabetes mellitus (NIDDM) and in the control group consisting of healthy subjects. The insert ion allele (I) and genotype II were found to be associated with NIDDM. The frequencies of diabetic retinopathy and nephropathy in NIDDM patients were not associated with this polymorphism. However, an association was found be tween the DD genotype of the ACE gene and diabetic angiopathy in lower extr emities.