A genomic-systems biology map for cardiovascular function

With the draft sequence of the human genome available, there is a need to b etter define gene function in the context of systems biology. We studied 23 9 cardiovascular and renal phenotypes in 113 mate rats derived from an F-2 intercross and mapped 81 of these traits onto the genome. Aggregates of tra its were identified on chromosomes 1, 2, 7, and 18. Systems biology was ass essed by examining patterns of correlations ("physiological profiles") that can be used for gene hunting, mechanism-based physiological studies, and, with comparative genomics, translating these data to the human genome.