Regioselective hydrolysis of diesters of (Z)- and (E)-2-methyl-butenedioicacids by PLE

Authors
Schmid, R Partali, V Anthonsen, T Anthonsen, HW Kvittingen, L
Citation
R. Schmid et al., Regioselective hydrolysis of diesters of (Z)- and (E)-2-methyl-butenedioicacids by PLE, TETRAHEDR L, 42(48), 2001, pp. 8543-8545
Citations number
17
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
42
Issue
48
Year of publication
2001
Pages
8543 - 8545
Database
ISI
SICI code
0040-4039(20011126)42:48<8543:RHODO(>2.0.ZU;2-B
Abstract
Dimethyl, diethyl and dipropyl esters of (Z)- and (E)-2-methyl-butenedioic acids (citraconic and mesaconic acid) were hydrolysed by pig live esterase, PLE. For the diethyl esters the enzyme showed low regio selectivity for bo th the (Z)- and the (E)-isomers. However, the hydrolysis of dimethyl and di propyl (Z)-2-methyl-butenedioic acid gave a ratio of the monoesters of 95:5 and 85:15. (C) 2001 Elsevier Science Ltd. All rights reserved.