Influence of pH and temperature on the enantioselectivity of propan-2-ol-treated Candida rugosa lipase in the kinetic resolution of (+/-)-4-acetoxy-[2,2]-paracyclophane

Authors
Cipiciani, A Bellezza, F Fringuelli, F Silvestrini, MG
Citation
A. Cipiciani et al., Influence of pH and temperature on the enantioselectivity of propan-2-ol-treated Candida rugosa lipase in the kinetic resolution of (+/-)-4-acetoxy-[2,2]-paracyclophane, TETRAHEDR-A, 12(16), 2001, pp. 2277-2281
Citations number
19
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON-ASYMMETRY
ISSN journal
09574166 → ACNP
Volume
12
Issue
16
Year of publication
2001
Pages
2277 - 2281
Database
ISI
SICI code
0957-4166(20010913)12:16<2277:IOPATO>2.0.ZU;2-W
Abstract
The reaction temperature, pH of the aqueous medium and use of an aqueous-n- hexane reaction medium markedly influenced the hydrolysis rate and enantios electivity of (+/-)-4-acetoxy-[2,2]-paracyclophane with propan-2-ol-treated Candida rugosa lipase. The results have been justified on the bask of a po ssible conformational change in the enzyme as a consequence of the displace ment of its polypeptide lid. (C) 2001 Elsevier Science Ltd. All rights rese rved.