New DR5 sequences: a novel DRB1*11122 allele identified in Paiwan tribe members of Taiwan and a corrected sequence for the DRB1*1201 allele

We report herein the identification of a new DRB1 allele using sequence-bas ed typing (SBT). This novel allele, HLA-DRB1*11122, was typing found in an aboriginal individual (SWP71) from the Paiwan tribe in the southern part of Taiwan. This individual was typed by SBT method as having an HLA genotype of HLA-A*24021/24021, HLA-B*4001/4002, This study was supported in part by grants from HL4-DRB3*0202, and HL4-DRB5*01011. This new allele differs from DPB1*1112 in the polymorphic exon 2 only at codon 34 (CAA --> CAG; both sp ecify glutamine) and from DRB1*11110 in the exon 2 sequence only at codon 3 2 (CAT --> TAT: H32T). The most likely candidate allele which is found in t he aboriginal populations of Taiwan and which may mutate into this new alle le is DRB1*11011. DRB1*11122 allele differs from DRB1*11011 allele in the p olymorphic exon 2 at both codon 34 (CAA --> CAG) and codon 37 (TAC --> TTC; T37F). This novel HLA-DRB1*11122 allele was also found in another aborigin al individual (SWP90) from the same Paiwan tribe. This SWP90 individual was typed by SBT method as having an HLA genotype of HLA-A 4T4021124021, HLA-B *40021 5502, HLA-DPB1*11122/1201, and HLA-DRB3*01011/0202. However, the ori ginal DRB1*1201 sequence from HERLUFF was found to be erroneously reported and the corrected sequence from SWP90 is now presented herein.