Domains of apolipoprotein E involved in the binding to the protein core ofbiglycan of the vascular extracellular matrix - Potential relationship between retention and anti-atherogenic properties of this apolipoprotein

We recently identified elements in the C-terminal domain of apolipoprotein E that are critical for the binding of this protein to the protein core of biglycan, a proteoglycan of the vascular extracellular matrix. This binding , ionic in nature, requiring no participation by glycosaminoglycans, sugges ts that protein-protein interactions may play an important role in the bind ing of apolipoprotein E to the extracellular matrix. These interactions may represent a potential mechanism for the anti-atherogenic potential of this apolipoprotein by preventing further anchoring to the vascular matrix of p ro-atherogenic factors. (Trends Cardiovasc Med 2001; 11:263-268). (C) 2001, Elsevier Science Inc.