Controlling malaria: challenges and solutions

Antimalarial drug resistance is a major public health challenge and the pri ncipal reason for the erosion of efficacious treatments. Cost and the limit ed number of antimalarial drugs in current use impose considerable constrai nts on malaria control, especially in sub-Saharan Africa. The paper describ es a multilateral, multidisciplinary research project on artemisinin-based combination therapy, which offers a new and potentially highly effective wa y to prevent or retard the development of drug resistance.