Spectrophotometric determination of propranolol as Cu(II), Ni(II) and Co(II) dithiocarbamate complexes

A spectrophotometric method was developed for the determination of the beta adrenergic blocking drug propranolol. The method was based on the formatio n of Cu(II), Ni(II) and Co(II)-dithiocarbamate complexes from the secondary amine group of propranolol with carbondisulfide (CS2) and the acetate salt s of the metals in ammonia medium. The method was applied to the analysis of propranolol tablets and the resul ts were statistically compared with those obtained by the official method u sing t- and F-tests. There was no significant difference between the mean v alues and the precisions of the two methods at the 95% confidence level.