Re-occurrence of HIV-1 drug mutations after treatment re-initiation following interruption in patients with multiple treatment failure

Authors
Delaugerre, C Valantin, MA Mouroux, M Bonmarchand, M Carcelain, G Duvivier, C Tubiana, R Simon, A Bricaire, F Agut, H Autran, B Katlama, C Calvez, V
Citation
C. Delaugerre et al., Re-occurrence of HIV-1 drug mutations after treatment re-initiation following interruption in patients with multiple treatment failure, AIDS, 15(16), 2001, pp. 2189-2191
Citations number
11
Categorie Soggetti
Immunology
Journal title
AIDS
ISSN journal
02699370 → ACNP
Volume
15
Issue
16
Year of publication
2001
Pages
2189 - 2191
Database
ISI
SICI code
0269-9370(20011109)15:16<2189:ROHDMA>2.0.ZU;2-X
Abstract
Antiretroviral treatment interruption in 20 extensively pre-treated HIV-1 p atients with treatment failure led to genotype viral reversion of at least one class of drug-mutation resistance in half of the patients. The only pre dictive factor of reversion was found to be the duration of interruption. T he outgrowth of residual wild-type virus seems not to be a true genetic rev ersion because drug mutations are detected rapidly at salvage therapy re-in itiation.