Mof. Al-othman et al., Radiotherapy alone for clinical T4 skin carcinoma of the head and neck with surgery reserved for salvage, AM J OTOLAR, 22(6), 2001, pp. 387-390
Purpose: To evaluate the outcomes of definitive radiotherapy in the treatme
nt of clinical stage T4 cutaneous carcinomas of the head and neck.
Patients and Methods. Between October 1964 and September 1997, 85 patients
with 88 biopsy-proven clinical AJCC stage T4 carcinomas of the skin of the
head and neck received radiotherapy with curative intent. A total of 43 les
ions were previously untreated, and 45 were recurrent after other treatment
modalities. Histologic types of carcinoma included squamous cell (37 lesio
ns), basal cell (41 lesions), and metatypical basal (basosquamous) cell (10
lesions). Minimum follow-up was 2 years. The product-limit method was used
to determine the rates of disease control, severe late complications, and
survival. Multivariate analyses included histology, previous treatment, inv
olvement of bone or nerve, number of structures invaded, node stage, extern
al beam dose, and overall treatment time.
Results: At 5 years, the rates of local control after radiotherapy and ulti
mate local control after salvage surgery were 53% and 90%, respectively. Lo
cal control rates were better for patients having previously untreated lesi
ons (P = .05). Regional and ultimate regional control rates were 93% and 10
0%, respectively, and were better for previously untreated lesions (P < .01
), basal cell histology or its metatypical variant (P = .04), and absence o
f bone invasion (P = .08). At 5 years, the risk of severe late complication
s was 17%, the risk of distant metastasis was 5%, and the overall absolute
and cause-specific survival probabilities were 56% and 76%, respectively.
Conclusion: Radiotherapy alone results in a relatively high probability of
cure for selected patients with T4 skin cancers. Copyright (C) 2001 by W.B.
Saunders Company.