Polyethylene glycol/surfactant mixtures improve lung function after HCl and endotoxin lung injuries

Citation
Kw. Lu et al., Polyethylene glycol/surfactant mixtures improve lung function after HCl and endotoxin lung injuries, AM J R CRIT, 164(8), 2001, pp. 1531-1536
Citations number
30
Categorie Soggetti
Cardiovascular & Respiratory Systems","da verificare
Journal title
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
ISSN journal
1073449X → ACNP
Volume
164
Issue
8
Year of publication
2001
Pages
1531 - 1536
Database
ISI
SICI code
1073-449X(20011015)164:8<1531:PGMILF>2.0.ZU;2-1
Abstract
Addition of nonionic polymers such as polyethylene glycol (PEG) and dextran ameliorates inactivation of Survanta by a variety of substances in vitro, Addition of polymers to Survanta also improves pulmonary function when used to treat rats with lung injury caused by instillation of human meconium. T o find whether this approach is effective in lung injuries that more closel y resemble adult respiratory distress syndrome (ARDS), we have compared the use of Survanta with Survanta + PEG in two additional models of lung injur y caused by either lipopolysaccharide (LPS) or HCI in adult rats. Significa nt improvement of serial measures for arterial oxygenation and of postmorte m pressure-volume measurements were found after treatment with Survanta + P EG compared with Survanta alone. PEG added to Survanta increased resistance to inactivation caused by tracheal fluid taken from animals injured with H CI. Other work suggests that PEG promotes surfactant aggregation, separates surfactant from surfactant inhibitors, and enhances access of surfactant t o the gas-liquid interface. The addition of polymers to surfactants may als o be useful in the treatment of lung injury where inactivation of surfactan t has already occurred.