An acute reduction of the oxygen supply to contracting muscles not only aff
ects their metabolism but also modifies their sensorimotor control through
changes in afferent discharge of the group I and group III-IV nerve fibers,
the latter playing a pivotal role in the protective mechanisms against mus
cle fatigue. The effects of chronic hypoxemia on the muscle sensitivity are
totally unknown. In the present study, group I fibers (mechanosensory affe
rents) and group III-IV fibers (mechanosensory and chemosensory afferents)
from the anterior tibial muscle were recorded in normoxemic and chronic hyp
oxemic rats. Hypoxemic rats breathed for 45 d a gas mixture containing 9.5
to 10% O-2 in N-2. The data were compared. with those obtained in normoxemi
c animals of the same age. To activate the different muscle afferents, we u
sed different test agents, including electrically induced fatigue (EIF), KC
l lactic acid injections, as well as tendon vibrations. The conduction velo
city of all nerve fibers was significantly (p < 0.01) higher in hypoxemic r
ats than in the normoxemic group. Chronic hypoxemia significantly depressed
the response of the group III-IV muscle afferents to KCI injections and ev
en abolished their response to lactic acid and EIF. However, the response t
o tendon vibrations of the group I afferents was similar in hypoxemic and n
ormoxemic rats. These results suggest that chronic hypoxemia markedly alter
s the chemosensitivity of the group III-IV muscle afferents, which may expl
ain the higher fatigability of hypoxemic subjects.