Predictors of positive axillary lymph nodes after sentinel lymph node biopsy in breast cancer

Objective: The purpose of this study was to determine the factors that pred ict the presence of metastasis in nonsentinel lymph nodes (SLN) when the SL N is positive. Methods: A prospective database was analyzed and included patients who unde rwent SLN biopsy for invasive breast cancer from July 1997 to August 2000 ( n = 442). One hundred (22.6%) patients had one or more positive SLNs, and w ere analyzed to determine factors that predicted additional positive axilla ry nodes. Results: Of the 100 patients with a positive SLN, 40 patients (40%) had add itional metastasis in non-SLNs. The only significant variables that predict ed non-SLN metastasis were tumor lymphovascular invasion (P = 0.004), extra nodal extension (P < 0.001), and increasing size of the metastasis within t he SLN (P = 0.011). In analyzing just those patients who had lymphovascular invasion, extranodal extension, and a SLN metastasis > 2mm, 92% were found to have additional positive nodes. Conclusions: In patients with invasive breast cancer and a positive sentine l lymph node, lymphovascular invasion, extranodal extension, and increasing size of the metastasis all significantly increase the frequency of additio nal positive nodes. (C) 2001 Excerpta Medica, Inc. All rights reserved.