Interaction with a phospholipid, monolayer on a mercury electrode - Multivariate analysis of impedance data

Dioleyl phosphatidylcholine (DOPC) monolayer coated mercury electrodes were investigated with electrochemical impedance spectroscopy. The data from ex periments with coated electrodes in contact with different electrolytes was analysed with principal component analysis and regression methods to chara cterise the significant features of the various impedance spectra. It is sh own by combining multivariate analysis and electrochemical impedance spectr oscopy that it is possible to differentiate between the various spectra fro m measurements in KCl, NaCl, CsCl, and LiCl, respectively. Some aspects of drug interaction, doxorubicin, with the monolayer are also discussed. (C) 2 001 Elsevier Science B.V. All rights reserved.