Mechanism of action of the des-F(6) quinolone BMS-284756 measured by supercoiling inhibition and cleavable complex assays

Authors
Wu, P Lawrence, LE Denbleyker, KL Barrett, JF
Citation
P. Wu et al., Mechanism of action of the des-F(6) quinolone BMS-284756 measured by supercoiling inhibition and cleavable complex assays, ANTIM AG CH, 45(12), 2001, pp. 3660-3662
Citations number
13
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
00664804 → ACNP
Volume
45
Issue
12
Year of publication
2001
Pages
3660 - 3662
Database
ISI
SICI code
0066-4804(200112)45:12<3660:MOAOTD>2.0.ZU;2-Z
Abstract
BMS-284756 (T-3811ME), a novel des-F(6) quinolone, was tested in the superc oiling inhibition and cleavable complex assays against Escherichia coli DNA gyrase, a target of quinolones. The results suggest that BMS-284756 has th e same mechanism of action against DNA gyrase as other quinolones and a sim ilar level of potency.