Outbreak of cefozopran (Penicillin, oral cephems, and aztreonam)-resistantNeisseria gonorrhoeae in Japan

Authors
Muratani, T Akasaka, S Kobayashi, T Yamada, Y Inatomi, H Takahashi, K Matsumoto, T
Citation
T. Muratani et al., Outbreak of cefozopran (Penicillin, oral cephems, and aztreonam)-resistantNeisseria gonorrhoeae in Japan, ANTIM AG CH, 45(12), 2001, pp. 3603-3606
Citations number
10
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
00664804 → ACNP
Volume
45
Issue
12
Year of publication
2001
Pages
3603 - 3606
Database
ISI
SICI code
0066-4804(200112)45:12<3603:OOC(OC>2.0.ZU;2-I
Abstract
We have previously reported that the Neisseria gonorrhoeae isolates from cl inical failure cases treated with cefdinir and aztreonam, beta -lactams exh ibited high MICs. These resistant isolates were clearly separated from the isolates exhibiting a low level of resistance to P-lactams as shown by the MIC distribution of cefozopran. Restriction fragment length polymorphism DN A typing revealed that the outbreak of cefozopran-resistant isolates in Kit akyushu, Japan, occurred as a result of clonal spread.