In vitro antibacterial activities of AF 3013, the active metabolite of prulifloxacin, against nosocomial and community Italian isolates

Authors
Montanari, MP Mingoia, M Varaldo, PE
Citation
Mp. Montanari et al., In vitro antibacterial activities of AF 3013, the active metabolite of prulifloxacin, against nosocomial and community Italian isolates, ANTIM AG CH, 45(12), 2001, pp. 3616-3622
Citations number
11
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
00664804 → ACNP
Volume
45
Issue
12
Year of publication
2001
Pages
3616 - 3622
Database
ISI
SICI code
0066-4804(200112)45:12<3616:IVAAOA>2.0.ZU;2-9
Abstract
AF 3013, the active Metabolite of prulifloxacin, was tested to determine it s inhibitory and bactericidal activities against 396 nosocomial and 258 com munity Italian isolates. Compared with that of ciprofloxacin, its activity (assessed in MIC and minimal bactericidal concentration tests) was generall y similar or greater against gram-positive bacteria and greater against gra m-negative bacteria. In time-kill assays using selected isolates, its bacte ricidal activity was comparable to that of ciprofloxacin.