Lack of emergence of cytomegalovirus UL97 mutations conferring ganciclovir(GCV) resistance following preemptive GCV therapy in allogeneic stem cell transplant recipients

Authors
Gilbert, C Roy, J Belanger, R Delage, R Beliveau, C Demers, C Boivin, G
Citation
C. Gilbert et al., Lack of emergence of cytomegalovirus UL97 mutations conferring ganciclovir(GCV) resistance following preemptive GCV therapy in allogeneic stem cell transplant recipients, ANTIM AG CH, 45(12), 2001, pp. 3669-3671
Citations number
29
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
00664804 → ACNP
Volume
45
Issue
12
Year of publication
2001
Pages
3669 - 3671
Database
ISI
SICI code
0066-4804(200112)45:12<3669:LOEOCU>2.0.ZU;2-Q
Abstract
Fifty allogeneic stem cell transplant recipients were enrolled in a prospec tive cytomegalovirus pp65 antigenemia-guided preemptive therapy trial. Amon g these, 10 of 34 patients who received ganciclovir exhibited sustained and /or recurrent antigenemia despite treatment. Thirteen leukocyte preparation s from these 10 subjects were screened for the presence of the most frequen t cytomegalovirus UL97 mutations conferring ganciclovir resistance. None of these mutations were detected after mean and median ganciclovir exposures of 31.6 and 28.0 days, respectively.