Hyperbaric oxygen as an adjunct in zygomycosis: Randomized controlled trial in a murine model

Authors
Barratt, DM Van Meter, K Asmar, P Nolan, T Trahan, C Garcia-Covarrubias, L Metzinger, SE
Citation
Dm. Barratt et al., Hyperbaric oxygen as an adjunct in zygomycosis: Randomized controlled trial in a murine model, ANTIM AG CH, 45(12), 2001, pp. 3601-3602
Citations number
14
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
00664804 → ACNP
Volume
45
Issue
12
Year of publication
2001
Pages
3601 - 3602
Database
ISI
SICI code
0066-4804(200112)45:12<3601:HOAAAI>2.0.ZU;2-T
Abstract
Zygomycosis was induced by injecting CD-1 mice with 5 mg of intraperitoneal deferoxamine and then 10(6) CFU of intravenous and intrasinus Rhizopus arr hizus. The addition of hyperbaric oxygen (2.0 atm absolute twice daily) to amphotericin B did not improve survival over that achieved with amphoterici n B and placebo air treatments.