Unprecedented sugar-dependent in vivo antitumor activity of carbohydrate-pendant cis-diamminedichloroplatinum(II) complexes

Authors
Mikata, Y Shinohara, Y Yoneda, K Nakamura, Y Brudzinska, I Tanase, T Kitayama, T Takagi, R Okamoto, T Kinoshita, I Doe, M Orvig, C Yano, S
Citation
Y. Mikata et al., Unprecedented sugar-dependent in vivo antitumor activity of carbohydrate-pendant cis-diamminedichloroplatinum(II) complexes, BIOORG MED, 11(23), 2001, pp. 3045-3047
Citations number
15
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
23
Year of publication
2001
Pages
3045 - 3047
Database
ISI
SICI code
0960-894X(200112)11:23<3045:USIVAA>2.0.ZU;2-4
Abstract
Eight carbohydrate-pendant platinum(II) complexes have been synthesized fro m carbohydrate-diamine conjugates. D-Glucose, D-mannose, D-galactose, D-xyl ose, and L-glucose are attached to the dichloroplatinum(II) moiety by 1,3- or 1,2-diaminopropane chelates through with an O-glycoside bond. All the ca rbohydrate moieties reduced the toxicity inherent with platinum(II) complex es. (C) 2001 Elsevier Science Ltd. All rights reserved.