Successful allogeneic engraftment of mismatched unrelated cord blood following a nonmyeloablative preparative regimen

Reduction in the toxicity of allogeneic transplantation with nonmyeloablati ve induction regimens has expanded the scope of practice to older and more debilitated patients. However, the limited availability of matched sibling donors requires that alternative donor sources be investigated. Reported he re are 2 cases of patients with advanced hematologic malignancies without m atched siblings, partially matched family members, or matched unrelated don ors who successfully underwent nonmyeloablative conditioning therapy follow ed by infusion of partially matched, unrelated-donor cord blood cells. The patients are in remission and remain 100% donor as assessed by short tandem repeat analysis of the marrow 6 and 12 months following transplantation. ( Blood. 2001;98:3486-3488) (C) 2001 by The American Society of Hematology.