Epibatidine, a nicotinic acetylcholine receptor agonist, inhibits the capsaicin response in dorsal root ganglion neurons

Authors
Zhang, XF McKenna, DG Briggs, CA
Citation
Xf. Zhang et al., Epibatidine, a nicotinic acetylcholine receptor agonist, inhibits the capsaicin response in dorsal root ganglion neurons, BRAIN RES, 919(1), 2001, pp. 166-168
Citations number
18
Categorie Soggetti
Neurosciences & Behavoir
Journal title
BRAIN RESEARCH
ISSN journal
00068993 → ACNP
Volume
919
Issue
1
Year of publication
2001
Pages
166 - 168
Database
ISI
SICI code
0006-8993(20011116)919:1<166:EANARA>2.0.ZU;2-9
Abstract
In patch-clamp recordings from small-medium diameter dorsal root ganglion n eurons in culture, (+/-)-epibatidine (1 muM) was. able to inhibit the capsa icin response (IC50=0.32 muM) in neurons Where there was no detectable dire ct nicotinic response. Thus, (+/-)-epibatidine may inhibit the vanilloid re ceptor in. a manner that is not dependent upon nicotinic current activation , representing another mechanism by which such ligands could modulate vanil loid receptor signaling. (C) 2001 Elsevier Science BY All rights reserved.