Acquired immune deficiency syndrome and the increase in non-Hodgkin lymphoma incidence in New Jersey from 1979 to 1996 - An age specific analysis

Background. in New Jersey, the age-adjusted incidence rate of non-Hodgkin l ymphoma (NHL) increased more than a third from 1979 to 1996, the largest in crease among the major-cancers. Methods. Data from a linkage of New Jerseys population-based cancer and acq uired immune deficiency syndrome (AIDS) registries were used to obtain two sets of annual age specific incidence rates and estimated average annual pe rcentage changes in the incidence rates, for each of five adult age groups within each gender, from Poisson regression models that 1) included all the NHL cases and 2) excluded the cases of AIDS-NHL. Results. During 1979-1996, of the NHL cases aged 15 years and older reporte d to the cancer registry, 687 (6%) of the 11,725 male cases and 139 (1%) of the 10,785 female cases were AIDS-NHL. The highest percentages of AIDS-NHL were in the younger age groups-15-29, 30-39, and 40-49 years. Among both m en and women, average annual percentage increases in NHL occurred overall ( 3.1 and 3.0, respectively), and in each age group, ranging from 1.6 and 1.9 , respectively, in the 50-59 years age group to 6.6 and 4.2, respectively, in the 30-39 years age group (P much less than0.01). Excluding AIDS-NHL, th e estimated average annual percentage increases in NHL were greatest in the 30-39 and the 60 years and older age groups among men, and these two age g roups plus the 15-29 years age group among women, ranging between 2.4 and 2 .9 (P<0.05). Conclusions. As elsewhere, factors in addition to AIDS are involved in the increasing incidence of NHL in New Jersey. Because diagnostic and classific ation changes probably do not explain the entire increase unrelated to AIDS , other risk factors are likely responsible. Public health interventions to reduce the incidence of NHL not related to AIDS are problematic until more is known about the causes of NHL. Cancer 2001;92:2948-56. (C) 2001 America n Cancer Society.