Genetic polymorphism of cytochrome P450 2E1 in the Turkish population

CYP 2E1 is involved in metabolic activation of carcinogenic N-nitrosamines, benzene, urethane and other low molecular weight compounds. CYP2E1 gene is present in the population in various polymorphic forms. We detected the RF LP of the human CYP2E1 gene with the restriction endonuclease PstI, RsaI an d DraI in a group of 153 Turkish individuals. According to the results of t he PstI/RsaI analysis, 96.07% of the subjects were of the c1/c1 genotype, a nd 3.93% were of the c1/c2 genotype. In the DraI RFLP analysis, 84.30% DD g enotype, 15.03% CD genotype and 0.66% CC genotype were determined mined. Th e data obtained may be useful in epidemiological studies of the influence o f CYP2E1 polymorphism on carcinogenesis. Copyright (C) 2001 John Wiley & So ns, Ltd.