Increased incidence of multidrug-resistant tuberculosis in diabetic patients on the Bellevue Chest Service, 1987 to 1997

Study objectives: To investigate the characteristics of tuberculosis infect ion in diabetic patients at Bellevue Hospital. Design: We conducted a case-control study retrospectively reviewing the rec ords of patients at Bellevue Hospital Center from 1987 to 1997 with a disch arge diagnosis of tuberculosis and diabetes mellitus. Setting: Bellevue Hospital Center is a 1,200-bed, inner-city municipal hosp ital located in the Lower East Side of New York City. Patients: Fifty-three identified patients had verified tuberculosis infecti on and diabetes; of these, 50 charts were available for review. One hundred five control cases were selected from nondiabetic patients with a discharg e diagnosis of tuberculosis during the same time period. Measurements and results: Thirty-six percent (18 cases) of the patients wit h diabetes and tuberculosis had multidrug-resistant tuberculosis (MDR-TB) c ompared to only 10% (10 cases) in the control group (p<0.01) Controlling fo r homelessness, HIV status, and directly observed therapy, the relative ris k of MDR-TB was calculated to be 8.6 (confidence interval, 3.1 to 23.6) in the diabetic group compared to the control group. Conclusions: There was a significant association between diabetes and MDR-T B. Diabetes continues to be a risk factor for tuberculosis and was associat ed with MDR-TB in our patients.