M. Cattaneo et al., Low plasma levels of vitamin B-6 are independently associated with a heightened risk of deep-vein thrombosis, CIRCULATION, 104(20), 2001, pp. 2442-2446
Citations number
34
Categorie Soggetti
Cardiovascular & Respiratory Systems","Cardiovascular & Hematology Research
Background-Elevated plasma levels of total homocysteine (tHcy) before and a
fter an oral methionine load (PML) are associated with an elevated risk of
deep-vein thrombosis (DVT). We investigated whether plasma levels of B vita
mins that are involved in Hcy metabolism are associated with an elevated ri
sk of DVT.
Methods and Results-We compared 397 cases with previous DVT with 585 matche
d healthy controls. The plasma levels of folate, vitamin B-12, vitamin B-6,
and fasting and PML tHcy were measured. The ORs for DVT associated with hi
gh (> 95th percentile) fasting levels and PML increases of tHcy were 2.1 (9
5% CI, 1.2 to 3.4) and 2.4 (95% CI, 1.5 to 3.9) after adjustment for establ
ished risk factors for DVT. Fasting plasma levels and PML increases in tHcy
correlated negatively with vitamin levels. The crude OR for folate levels
in the lowest quartile compared with the highest was 1.5 (95% CI, 1.1 to 2.
1), and that for B-6 levels in the lowest and second quartiles compared wit
h the highest was 1.5 (95% CI, 1.0 to 2.1). However, after adjustment for e
stablished risk factors and fasting and PML tHcy, the ORs for B-6 levels in
the lowest and second quartiles only remained statistically significant (l
owest quartile: OR, 1.8; 95% Cl, 1.2 to 2.8, second quartile, OR, 1.9; 95%
CI, 1.3 to 2.9).
Conclusions-High fasting and PML tHcy and low vitamin B-6 plasma levels are
associated with an elevated risk for DVT independently of established risk
factors for DVT. The association of low vitamin B, levels with the risk fo
r DVT is independent of fasting and PML tHcy levels.