New horizons in the treatment of preterm premature rupture of membranes

This article reviews efforts to understand and develop methods to treat iat rogenic and spontaneous previable premature rupture of membranes (PPROM). T he current success rate with the amnio-patch suggests that iatrogenic PPROM should no longer be viewed as a devastating complication of pregnancy, but rather as a readily treatable condition. In a select group of patients wit h spontaneous PPROM there is the potential for developing a surgical techni que that may successfully graft the defect and allow the integrity of the a mniotic membrane to be restored.