Sp. Zhao et al., Impairment of endothelial function after a high-fat meal in patients with coronary artery disease, CORON ART D, 12(7), 2001, pp. 561-565
Objective To determine the effect of postprandial lipid changes on endothel
ial function in patients with coronary artery disease (CAD) after a high-fa
t meal.
Methods We studied 50 CAD patients and 25 control participants, who were al
l normocholesterolemic. Flow-mediated vasodilatation of the brachial artery
was evaluated by the high-resolution ultrasound technique before and after
a single high-fat meal (800 calories; 50 g fat).
Results Postprandial serum triglyceride level increased significantly at 2-
7 h and mean flow-mediated vasodilatation was impaired significantly (from
4.22 +/-0.44 to 2.75 +/-0.33%, P<0.01) for 75 subjects. The increment in 2
h serum triglyceride level correlated positively with the decrement in post
prandial flow-mediated vasodilatation (r=0.459, P<0.01). Postprandial trigl
yceride level was significantly higher in CAD patients than in control part
icipants. Flow-mediated vasodilatation was significantly impaired in CAD pa
tients (from 3.04 +/-0.39 to 1.69 +/-0.23%, P<0.01) and control participant
s (from 6.58<plus/minus>0.52 to 4.87 +/-0.19%, P<0.05) after a high-fat mea
l. The impairment of flow-mediated dilatation was more severe in CAD patien
ts (44.41%) than in control participants (25.99%, P<0.01).
Conclusion Postprandial endothelium-dependent vasodilatation after a single
high-fat meal was severely impaired in normocholesterolemic CAD patients a
nd control participants. The disordered postprandial metabolism of triglyce
ride-rich lipoproteins may play an atherogenic role by inducing endothelial
dysfunction. Coronary Artery Dis 12:561-565 (C) 2001 Lippincott Williams &
Wilkins.