Reduced fluoroquinolone susceptibility in Salmonella enterica serotypes intravelers returning from southeast Asia

During 1995 to 1999, we collected 1,210 Salmonella isolates; 629 were from Finnish travelers returning from abroad. These isolates were tested for sus ceptibility by determining MICs to ciprofloxacin, nalidixic acid, and seven additional antimicrobial agents. From 1995 to 1999, the annual proportion of reduced ciprofloxacin susceptibility (MIC greater than or equal to 0.125 mug/mL) among all travelers' isolates increased from 3.9% to 23.5% (p <0.0 01). The increasing trend was outstanding among the isolates from Southeast Asia; isolates from Thailand alone increased from 5.6% to 50.0% (p <0.001) . The reduced fluoroquinolone susceptibility was nonclonal in character and significantly associated with multidrug resistance. A point mutation in th e quinolone resistance-determining region of gyrA was present in all isolat es with reduced susceptibility. These data provide further evidence for the rapid spread of multidrug-resistant pathogens from one continent to anothe r.