Regression of primary high-grade gastric B-cell lymphoma following Helicobacter pylori eradication

The causative association between Helicobacter pylori and gastric mucosal i nflammation is well established. The inflammatory process leads to the acqu isition of mucosa-associated lymphoid tissue (MALT) by the stomach. Evidenc e links H. pylori gastritis with the development of low-grade primary gastr ic lymphoma with a phenotype specific for lymphoma of MALT type. It is now accepted that primary low-grade MALT lymphomas regress with H. pylori eradi cation therapy. However, the response of primary, diffuse, large-cell gastr ic lymphoma to H. pylori eradication therapy is still not established. We r eport a case of a primary high-grade gastric lymphoma regressing after H. p ylori eradication therapy. (C) 2001 Lippincott Williams & Wilkins.