Synthesis and absolute configuration of Nocardione A and B, furano-o-naphthoquinone-type metabolites of nocardia sp with antifungal, cytotoxic, and enzyme inhibitory activities

Authors
Tanada, Y Mori, K
Citation
Y. Tanada et K. Mori, Synthesis and absolute configuration of Nocardione A and B, furano-o-naphthoquinone-type metabolites of nocardia sp with antifungal, cytotoxic, and enzyme inhibitory activities, EUR J ORG C, (22), 2001, pp. 4313-4319
Citations number
8
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
ISSN journal
1434193X → ACNP
Issue
22
Year of publication
2001
Pages
4313 - 4319
Database
ISI
SICI code
1434-193X(200111):22<4313:SAACON>2.0.ZU;2-5
Abstract
(+/-)-Nocardione A (1), (S)-(-)-nocardione A, and (R)-(+)-nocardione B (2) were synthesized by starting from the enantiomers of propylene oxide and 5- benzyloxy (or methoxy)-1-tetralone. The absolute configurations of the natu rally occurring (-)-1 and (-)-2 were established as (S).