A domino spirocyclization to form lactams

Authors
Tietze, LF Steck, PL
Citation
Lf. Tietze et Pl. Steck, A domino spirocyclization to form lactams, EUR J ORG C, (22), 2001, pp. 4353-4356
Citations number
15
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
ISSN journal
1434193X → ACNP
Issue
22
Year of publication
2001
Pages
4353 - 4356
Database
ISI
SICI code
1434-193X(200111):22<4353:ADSTFL>2.0.ZU;2-M
Abstract
Spirocyclic amides are easily obtained from primary amines, cycloenones and acrylic acid methyl ester, The key step is a two-component domino process that includes the formation of an amide followed by a Michael addition in t he presence of trimethylaluminum.