STUDIES ON POTASSIUM CHANNEL OPENERS .1. SYNTHESIS AND CARDIOVASCULARACTIVITY OF SUBSTITUTED INO-3,4-DIHYDRO-2,2-DIMETHYL-2H-1-BENZOPYRAN-3-OLS

Thirteen novel substituted trans-4-amino-3, 4-dihydro-2, 2-dimethyl-2H -1-benzopyran-3-ols have been prepared and evaluated for their relaxan t activity in the anaesthetized normotensive sprague-dawley rats, The synthetic route to these compounds involves the conversion of 2H-1-ben zopyrans to bromohydrins, followed by conversion to epoxides, which we re ring opened with appropriate amines or acylhydrazines. Some of thes e compounds showed marked vasodilator and antihypertensive activities.