Association of Gc-globulin variation with susceptibility to COPD and diffuse panbronchiolitis

Chronic obstructive pulmonary disease (COPD) and diffuse panbronchiolitis ( DPB) are both characterized by chronic airflow limitation. Although the aet iology of these diseases is under investigation, it is commonly hypothesize d that neutrophils a major role in the disease pathogenesis. The variation of the genes related to chemotaxis of neutrophils may confer a risk for the development of both COPD and DPB. In the present report, the authors investigated the association between gen etic variation that codes for the 416th and 420th amino acid of Ge-globulin , reported to be associated with chemotaxis of neutrophils, and susceptibil ity to COPD and DPB. Blood samples obtained front patients with COPD (n=63) , DPB (n=82), and control subjects (n=82) were used for the genotyping assa y. The proportion of GC*1F homozygotes was significantly higher in the COPD pa tients than the control subjects (COPD 36.5% versus control 20.7%), and the odds ratio for GC*1F homozygotes was 2.2 (95% confidence interval 1.1-4.6) for the COPD group. There was no difference on the distribution of the oth er genotypes (GC*1F-1S heterozygotes, GC*1S homozygotes, GC*2-1F heterozygo tes, GC*2-1S heterozygotes and GC*2 homozygotes) or the allele frequencies among these groups. These findings suggest that the GC*1F gene polymorphism of Gc-globulin may be one of the risk factors for chronic obstructive pulmonary disease. Howev er, no association between this polymorphism of Ge-globulin and susceptibil ity to diffuse panbronchiolitis was found.