The effect of osmolality changes on gastric mucosal endogenous prostacyclin levels in drug-induced experimental ulcer model of rat

Authors
Gharzouli, K Balint, GA Galfi, M Rimanoczy, A Juhasz, A
Citation
K. Gharzouli et al., The effect of osmolality changes on gastric mucosal endogenous prostacyclin levels in drug-induced experimental ulcer model of rat, EXP TOX PAT, 53(5), 2001, pp. 409-411
Citations number
10
Categorie Soggetti
Pharmacology & Toxicology
Journal title
EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY
ISSN journal
09402993 → ACNP
Volume
53
Issue
5
Year of publication
2001
Pages
409 - 411
Database
ISI
SICI code
0940-2993(200110)53:5<409:TEOOCO>2.0.ZU;2-T
Abstract
Osmolality changes evoked with intragastric administration of natural honey or mannitol, significantly decreased the gastric ulceration of rats induce d by indomethacin. Together with this effect, a parallel increase was detec table in the mucosal level of endogenous prostacyclin. Although many proces ses may be involved in this phenomenon, the authors explain their data with a stimulating effect on gastric mucosal microcirculation due to osmolality changes.